Open AccessIncreased Program Cell Death–1 Expression on T Lymphocytes of Patients With Progressive Multifocal Leukoencephalopathy
Author(s) -
Chen Sabrina Tan,
Evelyn Bord,
Thomas Broge,
Brett Glotzbecker,
Heidi Mills,
Sarah Gheuens,
Jacalyn Rosenblatt,
David Avigan,
Igor J. Koralnik
Publication year - 2012
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31825a313c
Subject(s) - progressive multifocal leukoencephalopathy , cd8 , immune system , cytotoxic t cell , leukoencephalopathy , jc virus , immunology , t cell , medicine , slow virus , biology , virology , virus , disease , genetics , in vitro
The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4(+) and CD8(+) T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8(+) cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.