Open AccessAltered Vaginal Microbiota Are Associated With Perinatal Mother-to-Child Transmission of HIV in African Women From Burkina Faso
Author(s) -
Daniel N. Frank,
Olivier Manigart,
Valériane Leroy,
Nicolas Méda,
Diane Valéa,
Weimin Zhang,
François Dabis,
Norman R. Pace,
Philippe Van de Perre,
Edward N. Janoff
Publication year - 2012
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31824e4bdb
Subject(s) - gardnerella vaginalis , microbicide , sexual transmission , transmission (telecommunications) , bacterial vaginosis , odds ratio , pyrosequencing , benzalkonium chloride , medicine , pregnancy , logistic regression , biology , obstetrics , microbiology and biotechnology , immunology , physiology , human immunodeficiency virus (hiv) , pathology , biochemistry , genetics , electrical engineering , gene , engineering
Mother-to-child transmission (MTCT) of HIV remains a significant problem in resource-limited settings, despite the advent of antiretroviral therapies. Because perturbations in vaginal microbial communities are associated with sexual transmission of HIV, we determined whether perinatal MTCT is associated with the vaginal microbiotas of HIV-infected mothers.