Open AccessIncreased Platelet and Microparticle Activation in HIV Infection
Author(s) -
Elizabeth Mayne,
Nicholas T. Funderburg,
Scott F. Sieg,
Robert Asaad,
Magdalena Kalinowska,
Benigno Rodrı́guez,
Alvin H. Schmaier,
Wendy Stevens,
Michael M. Lederman
Publication year - 2012
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3182439355
Subject(s) - platelet , platelet activation , tissue factor , immunology , flow cytometry , microparticle , cd14 , population , immune system , medicine , biology , coagulation , environmental health , astrobiology
HIV-1-infected patients have an increased risk for atherothrombosis and cardiovascular disease, but the mechanism behind these risks is poorly understood. We have previously reported that expression of tissue factor (TF) on circulating monocytes is increased in persons with HIV infection and that TF expression is related to immune activation, to levels of HIV in plasma, and to indices of microbial translocation. In this study, we explore the activation state of platelets in HIV disease.