Open AccessInterleukin-2 Production by Polyfunctional HIV-1–Specific CD8 T Cells Is Associated With Enhanced Viral Suppression
Author(s) -
Olusimidele T. Akinsiku,
Anju Bansal,
Steffanie Sabbaj,
Sonya L. Heath,
Paul Goepfert
Publication year - 2011
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e318224d2e9
Subject(s) - biology , cytotoxic t cell , cd8 , t cell , viral replication , interleukin 21 , cytokine , immunology , immune system , virology , virus , in vitro , biochemistry
Assays to measure the induction of HIV-1-specific CD8 T-cell responses often rely on measurements of indirect effector function such as chemokine and cytokine production, which may not reflect direct elimination of an invading pathogen. Assessment of the functional ability of CD8 T cells to suppress HIV-1 replication has been viewed as a surrogate marker of an effectual immune response. To further investigate this, we measured the capacity of virus-specific CD8 T cells to inhibit HIV-1 replication in an in vitro suppression assay.