Open AccessImpact of Herpes Simplex Virus Type 2 on HIV-1 Acquisition and Progression in an HIV Vaccine Trial (the Step Study)
Author(s) -
Ruanne V. Barnabas,
Judith N. Wasserheit,
Yunda Huang,
Holly Janes,
Rhoda Ashley Morrow,
Jonathan Fuchs,
Karen E. Mark,
Martín Casapía,
Devan V. Mehrotra,
Susan Buchbinder,
Lawrence Corey
Publication year - 2011
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31821acb5
Subject(s) - viral load , hazard ratio , medicine , immunology , herpes simplex virus , confidence interval , proportional hazards model , virology , virus
Extensive observational data suggest that herpes simplex virus type 2 (HSV-2) infection may facilitate HIV acquisition, increase HIV viral load, and accelerate HIV progression and onward transmission. To explore these relationships, we examined the impact of preexisting HSV-2 infection in an international HIV vaccine trial.