Open AccessHIV-1–Infected Peripheral Blood Mononuclear Cells Enhance Neutrophil Survival and HLA-DR Expression Via Increased Production of GM-CSF: Implications for HIV-1 Infection
Author(s) -
Jun Fu,
Beverly E. Sha,
Larry L. Thomas
Publication year - 2011
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181fa1fa5
Subject(s) - peripheral blood mononuclear cell , immunology , human immunodeficiency virus (hiv) , human leukocyte antigen , peripheral blood , virology , medicine , biology , antigen , in vitro , biochemistry
HIV-1 bound to intact neutrophils efficiently infects activated peripheral blood mononuclear cells (PBMC). Here, we evaluated the effect of the local milieu created by activated PBMC before and after HIV-1 infection on neutrophil survival and HLA-DR expression, with emphasis placed on a role for GM-CSF.