HIV-1–Infected Peripheral Blood Mononuclear Cells Enhance Neutrophil Survival and HLA-DR Expression Via Increased Production of GM-CSF: Implications for HIV-1 Infection | Zendy

Jun Fu | Zendy; Beverly E. Sha | Zendy; Larry L. Thomas | Zendy

Open Access

HIV-1–Infected Peripheral Blood Mononuclear Cells Enhance Neutrophil Survival and HLA-DR Expression Via Increased Production of GM-CSF: Implications for HIV-1 Infection

Author(s) -

Jun Fu,

Beverly E. Sha,

Larry L. Thomas

Publication year - 2010

Publication title -

jaids journal of acquired immune deficiency syndromes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.162

H-Index - 157

eISSN - 1944-7884

pISSN - 1525-4135

DOI - 10.1097/qai.0b013e3181fa1fa5

Subject(s) - peripheral blood mononuclear cell , immunology , human immunodeficiency virus (hiv) , human leukocyte antigen , peripheral blood , virology , medicine , biology , antigen , in vitro , biochemistry

HIV-1 bound to intact neutrophils efficiently infects activated peripheral blood mononuclear cells (PBMC). Here, we evaluated the effect of the local milieu created by activated PBMC before and after HIV-1 infection on neutrophil survival and HLA-DR expression, with emphasis placed on a role for GM-CSF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research