Open AccessAntiretroviral Therapy Down-Regulates Innate Antiviral Response Genes in Patients With AIDS in Sub-Saharan Africa
Author(s) -
David R. Boulware,
David B. Meya,
Tracy L. Bergemann,
Darlisha A Williams,
Irina Vlasova-St. Louis,
Joshua Rhein,
Jack H. Staddon,
Andrew Kambugu,
Edward N. Janoff,
Paul R. Bohjanen
Publication year - 2010
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181ef4963
Subject(s) - innate immune system , immunology , immune system , biology , pattern recognition receptor , interferon , gene , virology , genetics
HIV pathogenesis is characterized by destructive imbalances between virus-mediated immune damage, antiviral immune responses, and immune activation. We characterized the effects of successful antiretroviral therapy (ART) to identify the breadth and patterns of HIV-associated gene expression.