Open AccessPhase I/II Trial of the Anti-HIV Activity of Mifepristone in HIV-Infected Subjects ACTG 5200
Author(s) -
Michael F. Para,
Jeff Schouten,
Susan L. Rosenkranz,
Yu Song,
David B. Weiner,
Pablo Tebas,
C. J. White,
Dominic N. Reeds,
Juan J.L. Lertora,
Kristine B. Patterson,
Eric S. Daar,
Winston Cavert,
Barbara Brizz
Publication year - 2010
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181d142cb
Subject(s) - mifepristone , human immunodeficiency virus (hiv) , virology , medicine , pharmacology , biology , genetics , pregnancy
Mifepristone is a glucocorticoid receptor inhibitor shown in vitro to have anti-HIV activity and anti-simian immunodeficiency virus activity in a macaque model. A phase I/II trial was performed to assess the drug's safety and anti-HIV activity.