Open AccessSpecific Phenotypic and Functional Features of Natural Killer Cells From HIV-Infected Long-Term Nonprogressors and HIV Controllers
Author(s) -
Vincent Vieillard,
Hugues Fausther-Bovendo,
Assia Samri,
Patrice Debré
Publication year - 2010
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181d0c5b4
Subject(s) - biology , cd16 , immunology , virology , phenotype , natural killer cell , immune system , innate immune system , interferon , viral replication , cytolysis , k562 cells , virus , cytotoxic t cell , cd3 , cd8 , gene , genetics , in vitro , leukemia
Recent evidence suggests that natural killer (NK) cells play a crucial role in the HIV pathogenesis. Long-term nonprogressor (LTNP) and HIV controllers are rare HIV-infected patients who control viral replication and show delayed disease progression. They represent fascinating models of natural protection against disease progression and for studying the immunological response to the virus.