Open AccessEvolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy
Author(s) -
Hiroyu Hatano,
Harry Lampiris,
Signe Fransen,
Surabhi Gupta,
Wei Huang,
Rebecca Hoh,
Jeffrey N. Martin,
Jacob Lalezari,
David R. Bangsberg,
Christos J. Petropoulos,
Steven G. Deeks
Publication year - 2010
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181c42ea4
Subject(s) - elvitegravir , raltegravir , integrase , integrase inhibitor , virology , biology , drug resistance , viral load , regimen , pharmacology , medicine , genetics , virus , human immunodeficiency virus (hiv) , antiretroviral therapy
Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined.