Open AccessEfavirenz Induces CYP2B6-Mediated Hydroxylation of Bupropion in Healthy Subjects
Author(s) -
Sarah Robertson,
Frank Maldarelli,
Ven Natarajan,
Elizabeth Formentini,
Raul M. Alfaro,
Scott Penzak
Publication year - 2008
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e318183a425
Subject(s) - bupropion , cyp2b6 , efavirenz , pharmacology , medicine , hydroxylation , virology , chemistry , cyp3a4 , biochemistry , viral load , human immunodeficiency virus (hiv) , metabolism , cytochrome p450 , smoking cessation , pathology , enzyme , antiretroviral therapy
To characterize the effect of efavirenz on bupropion hydroxylation as a marker of cytochrome P450 (CYP) 2B6 activity in healthy subjects.