Open AccessRegulation of Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Dopamine Receptor-Mediated Signaling Pathways
Author(s) -
Shaoying Lee,
Hongyu Deng,
Fuqu Yu,
William P. Melega,
Robert Damoiseaux,
Kenneth A. Bradley,
Ren Sun
Publication year - 2008
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31817fbdcf
Subject(s) - lytic cycle , kaposi's sarcoma associated herpesvirus , biology , virus latency , viral replication , activator (genetics) , virology , gammaherpesvirinae , signal transduction , microbiology and biotechnology , virus , receptor , herpesviridae , genetics , viral disease
Kaposi's sarcoma-associated herpesvirus (KSHV) possesses two distinct life cycles, lytic replication and latency. An immediate early viral protein, Replication and transcription activator (RTA), is responsible for the virus switch from latency to active replication.