Open AccessChemokine Responses Are Increased in HIV-Infected Malawian Children With Invasive Pneumococcal Disease
Author(s) -
Enitan D. Carrol,
Limangeni Mankhambo,
Paul Balmer,
Standwell C. Nkhoma,
Daniel L. Banda,
Malcolm Guiver,
Graham Jeffers,
Nick Makwana,
Elizabeth Molyneux,
Malcolm E. Molyneux,
Rosalind L Smyth,
C. A. Hart
Publication year - 2007
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31802f8390
Subject(s) - chemokine , immunology , ccl5 , medicine , cxcl10 , interleukin 8 , streptococcus pneumoniae , biology , inflammation , microbiology and biotechnology , immune system , t cell , il 2 receptor , antibiotics
Chemokines play an important role in the recruitment and regulation of leukocyte traffic during bacterial infection. The aims of this study were to investigate the chemokine response to invasive pneumococcal disease (IPD) and to examine the influence of HIV infection on the chemokine response, pneumococcal bacterial loads, and outcome.