Open AccessCD4:CD8 Ratio and CD8 Cell Count and Their Prognostic Relevance for Coronary Heart Disease Events and Stroke in Antiretroviral Treated Individuals: The Swiss HIV Cohort Study
Author(s) -
Frédérique Chammartin,
Katharine Darling,
Irene A. Abela,
Manuel Battegay,
Hansjakob Furrer,
Alexandra Calmy,
Enos Bernasconi,
Patrick Schmid,
Matthias Hoffmann,
Heiner C. Bucher
Publication year - 2022
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000003094
Subject(s) - hazard ratio , medicine , cd4 cd8 ratio , proportional hazards model , immunology , cohort , viral load , stroke (engine) , cd8 , immune system , confidence interval , human immunodeficiency virus (hiv) , mechanical engineering , lymphocyte subsets , engineering
HIV infection leads to a persistent expansion of terminally CD8 T cells and CD8 T suppressor cells, a marker of chronic immune activation leading to a low CD4:CD8 ratio that may persist in the presence of potent antiretroviral therapy and regained CD4 helper cells. It remains unclear whether a low CD4:CD8 ratio is associated with cardiovascular diseases.