Open AccessHealth Impact and Cost-Effectiveness of HIV Testing, Linkage, and Early Antiretroviral Treatment in the Botswana Combination Prevention Project
Author(s) -
Stephen Resch,
Julia H A Foote,
Kathleen Wirth,
Arielle Lasry,
Justine A Scott,
Janet Moore,
Fatma M. Shebl,
Tendani Gaolathe,
Mary K Feser,
Refeletswe Lebelonyane,
Emily P Hyle,
Mompati Mmalane,
Pamela Bachanas,
Liyang Yu,
Joseph Makhema,
Molly Pretorius Holme,
Max Essex,
Mary Grace Alwano,
Shahin Lockman,
Kenneth A. Freedberg
Publication year - 2022
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002996
Subject(s) - medicine , life expectancy , cost effectiveness , population , health care , incidence (geometry) , cost effectiveness analysis , cost–benefit analysis , quality adjusted life year , demography , environmental health , risk analysis (engineering) , physics , sociology , optics , economics , biology , economic growth , ecology
The Botswana Combination Prevention Project tested the impact of combination prevention (CP) on HIV incidence in a community-randomized trial. Each trial arm had ∼55,000 people, 26% HIV prevalence, and 72% baseline ART coverage. Results showed intensive testing and linkage campaigns, expanded antiretroviral treatment (ART), and voluntary male medical circumcision referrals increased coverage and decreased incidence over ∼29 months of follow-up. We projected lifetime clinical impact and cost-effectiveness of CP in this population.