Open AccessBrief Report: HIV Is Associated With Impaired Pulmonary Diffusing Capacity Independent of Emphysema
Author(s) -
Sarath Raju,
Jacquie Astemborski,
M. Bradley Drummond,
Hema C. Ramamurthi,
Jing Sun,
Robert H. Brown,
Gregory D. Kirk,
Meredith C. McCormack
Publication year - 2022
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002818
Subject(s) - dlco , medicine , copd , diffusing capacity , pulmonary function testing , odds ratio , cardiology , confounding , lung , lung function
HIV is associated with accelerated decline in lung function and increased risk for chronic obstructive pulmonary disease (COPD). Recently, there has been growing attention toward the impairment in the diffusing capacity of the lungs for carbon monoxide (DLCO), a marker of pulmonary gas exchange, observed among persons living with HIV. Although increased emphysema can contribute to the DLCO impairment observed, other factors may drive this association.