Open AccessPoorer Muscle Quality and Quantity With ART Initiation Is Associated With Greater Inflammation and Immune Activation
Author(s) -
Arianna Kousari,
Carlee Moser,
Maxine Olefsky,
Todd T. Brown,
Judith S. Currier,
Grace A. McComsey,
Ann Scherzinger,
James H. Stein,
Jordan E. Lake,
Kristine M. Erlandson
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002776
Subject(s) - inflammation , immune system , raltegravir , cd38 , medicine , skeletal muscle , endocrinology , immunology , chemistry , viral load , biology , antiretroviral therapy , human immunodeficiency virus (hiv) , stem cell , cd34 , genetics
We have previously shown that the initiation of antiretroviral therapy (ART) is associated with a decrease in skeletal muscle density (greater fat accumulation), suggesting that gains in lean body mass seen in many ART studies may reflect gains in low quality, fatty muscle. Here, we explore whether skeletal muscle density and area are associated with markers of inflammation and immune activation.