Open AccessUrine Cell-Free Mitochondrial DNA as a Marker of Weight Loss and Body Composition in Older Adults With HIV
Author(s) -
Carrie Johnston,
Eugenia L. Siegler,
Mary J. Rice,
Heather M. Derry,
Katie C. Hootman,
YuanShan Zhu,
Chelsie O Burchett,
Samir K. Gupta,
Mary E. Choi,
Marshall J. Glesby
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002766
Subject(s) - urine , medicine , albuminuria , urinary system , body mass index , creatinine , cross sectional study , physiology , endocrinology , renal function , pathology
Older adults with HIV (OAH) experience more comorbidities and geriatric syndromes than their HIV-negative peers, perhaps because of chronic inflammation. Cell-free mitochondrial DNA (cfmtDNA) released from cells undergoing necrosis-mediated cell death potentially acts as both a mediator and marker of inflammatory dysregulation. We hypothesized that urinary cfmtDNA would be associated with frailty, body composition, and fall history in OAH.