Open AccessHIV-1 Nucleic Acids Identify Rectal HIV Exposures in Self-Collected Rectal Swabs, Whereas Y-Chromosome Single Tandem Repeat Mixtures Are Not Reliable Biomarkers of Condomless Receptive Anal Intercourse
Author(s) -
Maria P. Lemos,
Vijay Nandi,
Joan Dragavon,
Ira Fleming,
Keertana Krishnan,
Martin Musuruana,
Madeline Kramer,
Hayley Glantz,
Michele P. Andrasik,
Robert W. Coombs,
M. Juliana McElrath,
HongVan Tieu
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002748
Subject(s) - medicine , men who have sex with men , anal intercourse , anal sex , human immunodeficiency virus (hiv) , immunology , syphilis
To focus interventions, biomarkers of HIV-1 exposure could help in identifying subpopulations at highest risk of acquisition. We assessed whether Y-chromosome single tandem repeat (YSTR) mixtures obtained from rectal swabs could serve as a biomarker of condomless receptive anal intercourse (CRAI) among men who have sex with men and transgender women and evaluated the feasibility of detecting HIV-1 virions to assess exposures.