Open AccessBrief Report: Subclinical Carotid Artery Atherosclerosis Is Associated With Increased Expression of Peripheral Blood IL-32 Isoforms Among Women Living With HIV
Author(s) -
Mohamed ElFar,
David B. Hanna,
Madéleine Durand,
Etienne Larouche-Anctil,
Mohamed Sylla,
Carl ChartrandLefebvre,
Guy Cloutier,
Jean-Philippe Goulet,
Seble Kassaye,
Roksana Karim,
Jorge R. Kizer,
Audrey L. French,
Stephen J. Gange,
Jason Lazar,
Howard N. Hodis,
JeanPierre Routy,
Petronela Ancuța,
Nicolas Chomont,
Alan Landay,
Robert C. Kaplan,
Cécile Tremblay
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002746
Subject(s) - medicine , subclinical infection , peripheral blood mononuclear cell , biomarker , body mass index , immunology , blood pressure , inflammation , proinflammatory cytokine , cytokine , endocrinology , gastroenterology , biology , biochemistry , in vitro
Persistent inflammation in HIV infection is associated with elevated cardiovascular disease (CVD) risk, even with viral suppression. Identification of novel surrogate biomarkers can enhance CVD risk stratification and suggest novel therapies. We investigated the potential of interleukin 32 (IL-32), a proinflammatory multi-isoform cytokine, as a biomarker for subclinical carotid artery atherosclerosis in virologically suppressed women living with HIV (WLWH).