Open AccessBrief Report: Ritonavir Concentrations in Hair Predict Virologic Outcomes in HIV-Infected Adolescents With Virologic Failure on Atazanavir-Based or Ritonavir-Based Second-Line Treatment
Author(s) -
Tariro Dianah Chawana,
Charles Nhachi,
Kusum Nathoo,
Bernard Ngara,
Hideaki Okochi,
Alan K. Louie,
Karen Kuncze,
David Katzenstein,
John Metcalfe,
Monica Gandhi,
Adolescent Treatment Failure study team
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002742
Subject(s) - ritonavir , atazanavir , medicine , human immunodeficiency virus (hiv) , virology , second line , viral load , first line , antiretroviral therapy
Suboptimal adherence to antiretroviral therapy (ART) is responsible for most virologic failure among adolescents with HIV. Methods for objectively measuring adherence to ART are limited. This study assessed the association between ritonavir concentrations in hair and self-reported adherence and modified directly administered ART on virologic outcomes among HIV-infected adolescents who were virologically failing second-line ART in Harare, Zimbabwe.