Open AccessLow-Level HIV RNA in Cerebrospinal Fluid and Neurocognitive Performance: A Longitudinal Cohort Study
Author(s) -
Albert M. Anderson,
Bin Tang,
Florin Vaida,
Daniel McCler,
Reena Deutsch,
Mariana Cherner,
Debra Cookson,
Melanie Crescini,
Igor Grant,
Ronald J. Ellis,
Scott Letendre
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002714
Subject(s) - interquartile range , neurocognitive , cerebrospinal fluid , viral load , medicine , cohort , cohort study , lentivirus , human immunodeficiency virus (hiv) , immunology , effects of sleep deprivation on cognitive performance , cognition , viral disease , psychiatry
Cognitive complications persist in persons with HIV during suppressive antiretroviral therapy (ART). Low levels of HIV during ART could contribute to these complications. In this study, we measured cerebrospinal fluid (CSF) HIV using a single-copy assay (SCA) to investigate a possible relationship between low-level HIV and cognition.