Open AccessPredicting HIV Incidence in the SEARCH Trial: A Mathematical Modeling Study
Author(s) -
Britta L Jewell,
Laura B. Balzer,
Tamara D. Clark,
Edwin D. Charlebois,
Dalsone Kwarisiima,
Moses R. Kamya,
Diane V. Havlir,
Maya Petersen,
Anna Bershteyn
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002684
Subject(s) - counterfactual thinking , population , incidence (geometry) , medicine , cohort , demography , statistics , environmental health , mathematics , psychology , social psychology , geometry , sociology
The SEARCH study provided community-based HIV and multidisease testing and antiretroviral therapy (ART) to 32 communities in East Africa and reported no statistically significant difference in 3-year HIV incidence. We used mathematical modeling to estimate the effect of control arm viral suppression and community mixing on SEARCH trial outcomes.