Open AccessBrief Report: Herpes Simplex Virus Type-2 Shedding and Genital Ulcers During Early HIV in Zimbabwean Women
Author(s) -
Rebecca G. Nowak,
Tobias A. Liska,
Søren M. Bentzen,
Esther Kim,
Tsungai Chipato,
Robert A. Salata,
David D. Celentano,
Charles Morrison,
Patti E. Gravitt
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002641
Subject(s) - medicine , herpes simplex virus , viral shedding , odds ratio , immunology , cohort , sex organ , virology , virus , biology , genetics
Herpes simplex virus type-2 (HSV-2) seropositive persons have a 3- to 5-fold higher risk of acquiring HIV, possibly because of HSV-2-induced inflammation and recruitment of susceptible immune cells to exposure sites. We hypothesized that cervical HSV-2 activation (ie, viral DNA shedding and/or ulcers) preceded HIV acquisition in the hormonal contraception and HIV cohort.