Open AccessChange in Circulating Undercarboxylated Osteocalcin (ucOCN) Is Associated With Fat Accumulation in HIV-Seropositive Women
Author(s) -
Arnold Z. Olali,
Anjali Sharma,
Qiuhu Shi,
Donald R. Hoover,
Kathleen M. Weber,
Audrey L. French,
Heather McKay,
Phyllis C. Tien,
Lena AlHarthi,
Michael T. Yin,
Ryan D. Ross
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002617
Subject(s) - serostatus , medicine , osteocalcin , endocrinology , physiology , linear regression , bayesian multivariate linear regression , human immunodeficiency virus (hiv) , viral load , immunology , biology , alkaline phosphatase , biochemistry , machine learning , computer science , enzyme
Bone mineral density loss and fat accumulation are common in people living with HIV. The bone-derived hormone, undercarboxylated osteocalcin (ucOCN) regulates fat metabolism. We investigated the relationship between ucOCN change and body fat change among perimenopausal/postmenopausal HIV-seronegative and HIV-seropositive women on long-term antiretrovirals.