Open AccessNLRP3 and IL-1β Gene Expression Is Elevated in Monocytes From HIV-Treated Patients With Neurocognitive Disorders
Author(s) -
Elham Mazaheri-Tehrani,
Minoo Mohraz,
Milesi,
Johanna Chester,
Anna De Gaetano,
Domenico Lo Tartaro,
SeyedAhmad SeyedAlinaghi,
Milad Gholami,
Sara De Biasi,
Lara Gibellini,
Anna Vittoria Mattioli,
Marcello Pinti,
Cristina Mussini,
Andrea Cossarizza
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002588
Subject(s) - neurocognitive , aim2 , inflammasome , asymptomatic , medicine , immunology , proinflammatory cytokine , dementia , interleukin 18 , inflammation , biomarker , interleukin , systemic inflammation , cytokine , disease , psychiatry , biology , cognition , biochemistry
Systemic immune activation and inflammation in chronic HIV infection are driving factors of non-AIDS-related events, including neurocognitive impairment. The role of inflammasome in monocytes from patients with HIV infection has been extensively studied, but its association with the extent of neurocognitive dysfunction has been poorly investigated.