Open AccessSchistosoma mansoni Infection Is Associated With a Higher Probability of Tuberculosis Disease in HIV-Infected Adults in Kenya
Author(s) -
Taryn McLaughlin,
Azhar Nizam,
Felix Odhiambo Hayara,
Gregory Ouma,
Angela Campbell,
Jeremiah Khayumbi,
Joshua Ongalo,
Samuel Gurrion Ouma,
N Sarita Shah,
John D. Altman,
Deepak Kaushal,
Jyothi Rengarajan,
Joel D. Ernst,
Henry M. Blumberg,
Lance A. Waller,
Neel R. Gandhi,
Cheryl L. Day,
David Benkeser
Publication year - 2021
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002536
Subject(s) - tuberculosis , schistosoma mansoni , immunology , mycobacterium tuberculosis , medicine , latent tuberculosis , coinfection , disease , immunity , schistosomiasis , human immunodeficiency virus (hiv) , helminths , immune system , pathology
Helminth infections can modulate immunity to Mycobacterium tuberculosis (Mtb). However, the effect of helminths, including Schistosoma mansoni (SM), on Mtb infection outcomes is less clear. Furthermore, HIV is a known risk factor for tuberculosis (TB) disease and has been implicated in SM pathogenesis. Therefore, it is important to evaluate whether HIV modifies the association between SM and Mtb infection.