Open AccessBrief Report: Discrepancies Between Self-Reported Adherence and a Biomarker of Adherence in Real-World Settings
Author(s) -
Shane Hebel,
Elijah Kahn-Woods,
Sheryl Malone-Thomas,
Marlene McNeese,
Lupita Thornton,
Adam Sukhija-Cohen,
Henna Patani,
Whitney Engeran,
Giffin Daughtridge
Publication year - 2020
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002486
Subject(s) - concordance , medicine , biomarker , confidence interval , urine , medication adherence , test (biology) , clinical trial , biochemistry , biology , paleontology , chemistry
Pre-exposure prophylaxis (PrEP) is only effective in preventing new HIV infections when taken consistently. In clinical practice, asking a patient about their adherence (self-report) is the predominant method of assessing adherence to PrEP. Although inexpensive and noninvasive, self-report is subject to social desirability and recall biases. Several clinical trials demonstrate a discrepancy between self-reported adherence and biomarker-based recent adherence. Less is known about the accuracy of self-report in real-world clinical settings. This brief report addresses this knowledge gap and describes the concordance between self-reported adherence and biomarker-based adherence in real-world clinical settings.