Open AccessBrief Report: Toll-like Receptor 9-1635A/G Polymorphism Is Associated With HIV-1 Rebound After Four Weeks of Interruption of Antiretroviral Therapy
Author(s) -
Alejandro Vallejo,
Sonia Molina-Pinelo,
Beatriz de Felipe,
María Abad-Fernández,
María Francisca GonzálezEscribano,
Manuel Leal,
Natalia Soriano-Sarabia
Publication year - 2020
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002437
Subject(s) - antiretroviral therapy , human immunodeficiency virus (hiv) , virology , toll like receptor , medicine , toll , polymorphism (computer science) , receptor , immunology , biology , genetics , viral load , genotype , gene , innate immune system
This study aims to analyze the association of the presence of common polymorphisms [single nucleotide polymorphisms (SNPs)] on Toll-like receptors (TLRs), such as TLR9-1635A/G, TLR2-1892A/C, TLR2-2258G/A, TLR4-899A/G, and TLR4-1196C/T, with the viral rebound after stopping antiretroviral treatment (ART). CCR5-Δ32 deletion and HLA-A/HLA-B alleles were also analyzed.