Open AccessComparison of [11C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals
Author(s) -
Anna H. Boerwinkle,
Jeremy F. Strain,
Tricia H. Burdo,
John Doyle,
Jon Christensen,
Yi Su,
Julie K. Wisch,
Sarah Cooley,
Florin Vaida,
Mandy D. Smith,
Hussain Jafri,
Robert Paul,
Tammie L.S. Benzinger,
Beau M. Ances
Publication year - 2020
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002435
Subject(s) - neuroinflammation , translocator protein , human immunodeficiency virus (hiv) , medicine , antiretroviral therapy , population , cognition , psychology , immunology , neuroscience , inflammation , viral load , environmental health
Despite combined antiretroviral therapy, neuroinflammation may persist in persons living with HIV (PLWH) and contribute to cognitive impairment in this population. Positron emission tomography (PET) imaging targeting 18 kDa translocator protein (TSPO) has been used to localize neuroinflammation. We aimed to use TSPO-PET imaging to evaluate neuroinflammation in PLWH.