Open AccessAntiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay
Author(s) -
Sulggi A. Lee,
Sushama Telwatte,
Hiroyu Hatano,
Angela D. M. Kashuba,
Mackenzie L. Cottrell,
Rebecca Hoh,
Teri Liegler,
Sophie Stephenson,
Ma Somsouk,
Peter W. Hunt,
Steven G. Deeks,
Steven A. Yukl,
Radojka M. Savic
Publication year - 2020
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002287
Subject(s) - raltegravir , rectum , lymph , viral load , digital polymerase chain reaction , lymphatic system , lymph node , ileum , antiretroviral therapy , colorectal cancer , reverse transcriptase , medicine , rna , pathology , biology , immunology , human immunodeficiency virus (hiv) , polymerase chain reaction , cancer , biochemistry , gene
Most HIV-infected cells during antiretroviral therapy (ART) persist in lymphoid tissues. Studies disagree on whether suboptimal tissue ART concentrations contribute to ongoing HIV replication during viral suppression.