Open AccessUse of Modeling and Simulations to Determine Raltegravir Dosing in Neonates: A Model for Safely and Efficiently Determining Appropriate Neonatal Dosing Regimens: IMPAACT P1110
Author(s) -
Diana F. Clarke,
Mark Mirochnick,
Edward P. Acosta,
Edmund V. Capparelli,
Anne Chain,
Hedy Teppler,
Betsy Smith,
Jos Lommerse
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002149
Subject(s) - dosing , raltegravir , regimen , medicine , population , cohort , pharmacokinetics , cohort study , pediatrics , intensive care medicine , pharmacology , viral load , human immunodeficiency virus (hiv) , immunology , environmental health , antiretroviral therapy
Population modeling and simulations can be used to facilitate the conduct of phase I studies to develop safe and effective dosing regimens in neonates.