Open AccessSome Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection
Author(s) -
Christian Deo T. Deguit,
Michelle Hough,
Rebecca Hoh,
Melissa Krone,
Christopher D. Pilcher,
Jeffrey N. Martin,
Steven G. Deeks,
Joseph M. McCune,
Peter W. Hunt,
Rachel L. Rutishauser
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002121
Subject(s) - cd8 , cytotoxic t cell , biology , immunology , t cell , flow cytometry , mhc class i , peripheral blood mononuclear cell , context (archaeology) , immune system , in vitro , biochemistry , paleontology
Reversing or preventing T-cell exhaustion is an important treatment goal in the context of HIV disease; however, the mechanisms that regulate HIV-specific CD8 T-cell exhaustion are incompletely understood. Since mitochondrial mass (MM), mitochondrial membrane potential (MMP), and cellular reactive oxygen species (ROS) content are altered in exhausted CD8 T cells in other settings, we hypothesized that similar lesions may arise in HIV infection.