Open AccessCognitive Trajectory Phenotypes in Human Immunodeficiency Virus–Infected Patients
Author(s) -
Raha Dastgheyb,
Ned Sacktor,
Donald Franklin,
Scott Letendre,
Thomas D. Marcotte,
Robert K. Heaton,
Igor Grant,
Justin C. McArthur,
Leah H. Rubin,
Norman J. Haughey
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002093
Subject(s) - cognition , verbal fluency test , population , cognitive decline , psychology , neuropsychology , cognitive test , verbal learning , dementia , recall , neurocognitive , medicine , psychiatry , cognitive psychology , disease , pathology , environmental health
The presentation of cognitive impairments in HIV-infected individuals has transformed since the introduction of antiretroviral therapies. Although the overall prevalence of cognitive impairments has not changed considerably, frank dementia is now infrequent, and milder forms of cognitive impairments predominate. Mechanistic insights to the underlying causes of these residual cognitive impairments have been elusive, in part due to the heterogenous etiology of cognitive dysfunction in this population. Here, we sought to categorize longitudinal change in HIV-infected patients based on the performance in specific cognitive domains.