Open AccessBrief Report: Impact of ART Classes on the Increasing Risk of Cerebral Small-Vessel Disease in Middle-Aged, Well-Controlled, cART-Treated, HIV-Infected Individuals
Author(s) -
Édouard Januel,
Ophélia Godin,
Antoine Moulignier,
François-Xavier Lescure,
Julien Savatovsky,
Cédric Lamirel,
Nadia Valin,
Roland Tubiana,
Ana Canestri,
Pascal Roux,
Jean-Claude Sadik,
Laurence Salomon,
Christine Katlama,
Yazdan Yazdanpanah,
Gilles Pialoux,
PierreMarie Girard,
Dominique Costagliola,
Lambert Assoumou
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000002084
Subject(s) - medicine , cart , disease , reverse transcriptase inhibitor , logistic regression , integrase inhibitor , case control study , viral load , immunology , antiretroviral therapy , human immunodeficiency virus (hiv) , engineering , mechanical engineering
Cerebral small-vessel disease (CSVD) is a chronic disease accounting for one-third of strokes and the second etiology of dementia. Despite sustained immunovirological control, CSVD prevalence is doubled in middle-aged persons living with HIV (PLHIVs), even after adjustment for traditional cardiovascular risk factors. We aimed to investigate whether exposure to any antiretroviral drug class could be associated with an increasing risk of CSVD.