Open AccessElevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women
Author(s) -
Juan Lin,
Xiaonan Xue,
Kathryn Anastos,
Mardge H. Cohen,
Stephen J. Gange,
Jason Lazar,
Chenglong Liu,
Wendy J. Mack,
Phyllis C. Tien,
Cathy Tilley,
Howard N. Hodis,
Alan Landay,
Russell P. Tracy,
Robert C. Kaplan,
David B. Hanna
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001988
Subject(s) - odds ratio , medicine , tissue factor , confidence interval , inflammation , risk factor , monocyte , immunology , gastroenterology , cardiology , coagulation
Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women.