Open AccessBrief Report: Higher Levels of Angiopoietin-1 Are Associated With Early and Sustained Viral Suppression in Children Living With Vertically Acquired HIV
Author(s) -
Vishrut Gulhati,
Jeremy Soo,
Doris G. Ransy,
Jason Brophy,
Fatima Kakkar,
Ari Bitnun,
Lindy Samson,
Stanley Read,
Hugo Soudeyns,
Michael Hawkes
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001955
Subject(s) - cart , medicine , viral load , confounding , biomarker , immunology , disease , endothelial activation , endothelial dysfunction , inflammation , human immunodeficiency virus (hiv) , biology , mechanical engineering , biochemistry , engineering
Systemic inflammation, platelet dysfunction, and endothelial activation persist in people living with HIV despite sustained virologic suppression (SVS) with combined antiretroviral therapy (cART) and may lead to complications such as atherosclerosis and cardiovascular disease. Angiopoietin-1 (Ang-1) is a key regulator of angiogenesis and endothelial activation and has been studied as an objective biomarker in disease states such as atherosclerosis, sepsis, and severe malaria.