Open AccessPeripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection
Author(s) -
Todd Hulgan,
Asha Kallianpur,
Yan Guo,
Jill S. BarnholtzSloan,
Haley Gittleman,
Todd T. Brown,
Ronald J. Ellis,
Scott Letendre,
Robert K. Heaton,
David C. Samuels,
Charter Study
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001930
Subject(s) - mitochondrial dna , copy number variation , genotyping , neurocognitive , biology , low copy number , genotype , genetics , medicine , genome , gene , cognition , neuroscience
Mitochondrial DNA (mtDNA) copy number varies by cell type and energy demands. Blood mtDNA copy number has been associated with neurocognitive function in persons without HIV. Low mtDNA copy number may indicate disordered mtDNA replication; high copy number may reflect a response to mitochondrial dysfunction. We hypothesized that blood mtDNA copy number estimated from genome-wide genotyping data is related to neurocognitive impairment (NCI) in persons with HIV.