Open AccessA Clinical Prediction Rule for Protease Inhibitor Resistance in Patients Failing Second-Line Antiretroviral Therapy
Author(s) -
Karen Cohen,
Alexander Stewart,
André Pascal Kengne,
Rory Leisegang,
Marla Coetsee,
Shavani Maharaj,
Liezl Dunn,
Michael Hislop,
Gert van Zyl,
Graeme Meintjes,
Gary Maartens
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001923
Subject(s) - interquartile range , lopinavir , medicine , viral load , atazanavir , confidence interval , ritonavir , odds ratio , immunology , antiretroviral therapy , human immunodeficiency virus (hiv)
Most adults with virological failure on second-line antiretroviral therapy (ART) in resource-limited settings have no major protease inhibitor (PI) resistance mutations. Therefore, empiric switches to third-line ART would waste resources. Genotypic antiretroviral resistance testing (GART) is expensive and has limited availability. A clinical prediction rule (CPR) for PI resistance could rationalize access to GART.