Open AccessReflexive Laboratory-Based Cryptococcal Antigen Screening and Preemptive Fluconazole Therapy for Cryptococcal Antigenemia in HIV-Infected Individuals With CD4 <100 Cells/µL: A Stepped-Wedge, Cluster-Randomized Trial
Author(s) -
David B. Meya,
Agnes Kiragga,
Elizabeth Nalintya,
Bożena M. Morawski,
Radha Rajasingham,
Benjamin J. Park,
Anthony Mubiru,
Jonathan E. Kaplan,
Yukari C. Manabe,
David R. Boulware
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001894
Subject(s) - medicine , hazard ratio , observational study , fluconazole , asymptomatic , confidence interval , randomized controlled trial , surgery , dermatology , antifungal
HIV-infected persons with cryptococcal antigenemia (CrAg) are at high risk for meningitis or death. We evaluated the effect of CrAg screening and preemptive fluconazole therapy, adjunctive to antiretroviral therapy (ART), on 6-month survival among persons with advanced HIV/AIDS.