Open AccessPD-1 Expression in HIV-Specific CD8+ T cells Before Antiretroviral Therapy Is Associated With HIV Persistence
Author(s) -
Yanina Alexandra Ghiglione,
César Ariel Trifone,
Jimena Salido,
Ajantha Rhodes,
María Julia Ruiz,
María L. Polo,
Horacio Salomón,
Natalia Laufer,
Omar Sued,
Sharon R. Lewin,
Gabriela Turk
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001887
Subject(s) - antiretroviral therapy , human immunodeficiency virus (hiv) , persistence (discontinuity) , virology , lentivirus , cd8 , immunology , sida , biology , medicine , viral load , viral disease , immune system , geotechnical engineering , engineering
The persistence of latently infected T cells remains the principal barrier to HIV cure. Understanding how the early immune responses shape persistence of HIV on antiretroviral therapy (ART) will be fundamental for potential eradication. Here, we aimed to determine the relationship between CD8 T-cell function and phenotype before therapy and HIV persistence on ART.