Open AccessObjective and Subjective Improvement of Cognition After Discontinuing Efavirenz in Asymptomatic Patients: A Randomized Controlled Trial
Author(s) -
Charlotte S. Hakkers,
Joop E. Arends,
Guido E van den Berk,
M.H.M. Ensing,
Imke Hooijenga,
Matthijs Vink,
M.J.E. van Zandvoort,
A. I. M. Hoepelman
Publication year - 2019
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001876
Subject(s) - efavirenz , asymptomatic , neurocognitive , randomized controlled trial , cognition , medicine , neuropsychology , effects of sleep deprivation on cognitive performance , pediatrics , psychiatry , human immunodeficiency virus (hiv) , viral load , immunology , antiretroviral therapy
Efavirenz is well known for its clinical cognitive side effects. Even asymptomatic patients who switch for other reasons than neurocognitive complaints have reported a subjective improvement in cognitive functioning after discontinuing efavirenz. The aim of this study was to assess the effect on cognition of switching Atripla (TDF/FTC/EFV) to Eviplera (TDF/FTC/RPV), hypothesizing an improvement when discontinuing efavirenz.