Open AccessBrief Report: Per Sex-Act Risk of HIV Transmission Under Antiretroviral Treatment: A Data-Driven Approach
Author(s) -
Virginie Supervie,
Romulus Breban
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001845
Subject(s) - serodiscordant , men who have sex with men , cart , transmission (telecommunications) , seroconversion , demography , sexual transmission , medicine , anal sex , emtricitabine , treatment as prevention , viral load , human immunodeficiency virus (hiv) , statistics , virology , antiretroviral therapy , mathematics , computer science , syphilis , geography , telecommunications , archaeology , sociology , microbicide
Before the completion of HPTN 052, PARTNER, and Opposites Attract studies, data were lacking to directly estimate HIV transmission risk under effective combined antiretroviral treatment (cART). Rather, estimates were obtained by extrapolating a dose-response relationship between viral load and risk of HIV transmission, observed among untreated individuals, to treated individuals. Presently, data have accumulated from 9 clinical studies for a direct validation of this extrapolation.