Open AccessAnalyses of Mitochondrial DNA and Immune Phenotyping Suggest Accelerated T-Cell Turnover in Treated HIV
Author(s) -
Marta Massanella,
Maile Y. Karris,
Josué Pérez-Santiago,
Christina Yek,
Andrej Vitomirov,
Sanjay R. Mehta
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001824
Subject(s) - immunosenescence , mitochondrial dna , cd8 , immune system , biology , t cell , immunology , senescence , cytotoxic t cell , mitochondrial toxicity , human immunodeficiency virus (hiv) , genetics , gene , in vitro
HIV infection is associated with premature aging, and mitochondrial integrity is compromised during the aging process. Because mitochondrial toxicity is a consequence of antiretroviral therapies (ARTs), we hypothesized HIV and long-term ART would correlate with immunosenescence and mitochondrial DNA (mtDNA) pathology.