Open AccessDevelopment and Calibration of a Mathematical Model of Anal Carcinogenesis for High-Risk HIV-Infected Men
Author(s) -
Emily A. Burger,
Michael A. Dyer,
Stephen Sy,
Joel M. Palefsky,
Alexandra de Pokomandy,
François Coutlée,
Michael J. Silverberg,
Jane J. Kim
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001727
Subject(s) - anal cancer , medicine , oncology , cancer , cohort , genotype , demography , disease , incidence (geometry) , cohort study , epidemiology , cervical cancer , immunology , biology , genetics , mathematics , geometry , sociology , gene
Men who have sex with men who are living with HIV are at highest risk for anal cancer. Our objective was to use empirical data to develop a comprehensive disease simulation model that reflects the most current understanding of anal carcinogenesis, which is uniquely positioned to evaluate future anal cancer screening strategies and provide insight on the unobservable course of the disease.