Open AccessBiomarkers of Aging in HIV-Infected Children on Suppressive Antiretroviral Therapy
Author(s) -
Stephanie Shiau,
Renate Strehlau,
Jing Shen,
Avy Violari,
Faeezah Patel,
Afaaf Liberty,
Marc Foca,
Shuang Wang,
Mary Beth Terry,
Michael T. Yin,
Ashraf Coovadia,
Elaine J. Abrams,
Stephen M. Arpadi,
Louise Kuhn
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001714
Subject(s) - dnam , cohort , viral load , medicine , telomere , immunology , biomarker , virology , pediatrics , human immunodeficiency virus (hiv) , biology , dna methylation , genetics , dna , gene expression , gene
Data on accelerated aging in HIV-infected children are limited. In this study, we assess 2 biomarkers of aging-telomere length and DNA methylation (DNAm) age-in a cohort of early-treated HIV-infected children and compare these aging biomarkers with HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children.