Open AccessImpact of HLA Allele-KIR Pairs on Disease Outcome in HIV-Infected Thai Population
Author(s) -
Masahiko Mori,
Nuanjun Wichukchinda,
Reiko Miyahara,
Archawin Rojanawiwat,
Panita Pathipvanich,
Toshiyuki Miura,
Michio Yasunami,
Koya Ariyoshi,
Pathom Sawanpanyalert
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001676
Subject(s) - human leukocyte antigen , immunology , biology , allele , population , cytotoxic t cell , viral load , antigen , medicine , genetics , human immunodeficiency virus (hiv) , gene , environmental health , in vitro
Class I human leukocyte antigen (HLA) molecules contribute to HIV control through antigen presentation to both cytotoxic T lymphocytes and natural killer cells. Contribution of cytotoxic T lymphocytes to HIV clinical outcome by HLA alleles has been well studied. However, reports about the role of natural killer cells in HIV clinical outcome, particularly, about the effect of HLA-killer immunoglobulin-like receptor (KIR) pairs, remain incomplete.