Open AccessNeprilysin in the Cerebrospinal Fluid and Serum of Patients Infected With HIV1-Subtypes C and B
Author(s) -
Sérgio Monteiro de Almeida,
Bin Tang,
Cléa Elisa Lopes Ribeiro,
Indianara Rotta,
Florin Vaida,
Mauro Piovesan,
Meire S. Batistela Fernandes,
Scott Letendre,
Michael Potter,
Ronald J. Ellis
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001666
Subject(s) - neprilysin , cerebrospinal fluid , transactivation , medicine , human immunodeficiency virus (hiv) , sida , viral load , immunology , biology , viral disease , transcription factor , enzyme , gene , biochemistry
Neprilysin (NEP) is the dominant Aβ peptide-degrading enzyme in the brain. HIV-1 subtype B transactivator of transcription protein is known to interfere with NEP function, but whether this is true of HIV-1C transactivator of transcription, which has a defective chemokine motif, is not known. This study aimed to analyze the impact of HIV subtype on NEP-mediated cleavage of Aβ by comparing cerebrospinal fluid (CSF) and serum levels of NEP between HIV+ (27 patients with HIV-1B and 26 with HIV-1C), healthy HIV- controls (n = 13), and patients with Alzheimer disease (n = 24).