Open AccessPharmacokinetics and Pharmacodynamics of Tenofovir Reduced-Glycerin 1% Gel in the Rectal and Vaginal Compartments in Women: A Cross-Compartmental Study With Directly Observed Dosing
Author(s) -
Jessica Justman,
Gonasagrie Nair,
Craig W. Hendrix,
Jeanna Piper,
Mark A. Marzinke,
Jiyan Dai,
Zhenyu Pan,
Beth Galaska,
Lisa Levy,
Jill L. Schwartz,
Bhavna Balar,
Ratiya Pamela Kunjara Na Ayudhya,
Ivy Mushamiri,
Ian McGowan,
Charlene S. Dezzutti,
Mtn Study Team
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001655
Subject(s) - dosing , pharmacokinetics , medicine , pharmacodynamics , compartment (ship) , rectal administration , anesthesia , oceanography , geology
Evidence is lacking regarding whether vaginal pre-exposure prophylaxis with topical tenofovir (TFV) reduces the risk of rectal HIV acquisition.