Open AccessBrief Report: Frequency of Monitoring Kidney Function in HIV-Uninfected Persons Using Daily Oral Tenofovir Disoproxil Fumarate Pre-exposure Prophylaxis
Author(s) -
Kenneth Mugwanya,
Jared M. Baeten,
Christina M. Wyatt,
Nelly Mugo,
Connie Celum,
Allan R. Ronald,
James Kiarie,
Elly Katabira,
Renee Heffron,
Partners PrEP Study
Publication year - 2018
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001575
Subject(s) - pre exposure prophylaxis , renal function , medicine , tenofovir , creatinine , human immunodeficiency virus (hiv) , kidney , prospective cohort study , urology , immunology , syphilis , men who have sex with men
Wide-scale implementation of oral tenofovir-based pre-exposure prophylaxis (PrEP) for HIV prevention is now policy in many settings. However, the optimal frequency for monitoring kidney function remains uncertain. We investigated the impact of 6-monthly compared with 3-monthly creatinine clearance (CrCl) monitoring on the identification of moderate kidney dysfunction, defined as CrCl <60 mL/min.